HALOTHANE HEPATITIS
نویسندگان
چکیده
منابع مشابه
Halothane macrophage migration inhibtiion factor test in halothane-associated hepatitis.
As an index of delayed hypersensitivity in vitro halothane macrophage migration inhibition factor tests (halothane-MIF tests) were performed on peripheral blood lymphocytes from five patients with halothane hepatitis. Twenty-two subjects exposed to halothane, but with no evidence of jaundice, five 'healthy' hospital anaesthetists, nine jaundiced subjects without halothane exposure, and 10 healt...
متن کاملHalothane hepatitis in a young child.
A 4-year-old girl developed severe hepatitis following the fourth administration of halothane in a period of 5 months. She was shown to have a circulating antibody which acted specifically against rabbit hepatocyte previously sensitized to halothane. The patient made a full recovery from the hepatitis, but 5 months later, developed diabetes mellitus.
متن کاملThe molecular basis of halothane-induced hepatitis.
Halothane hepatitis The anaesthetic agent halothane (CF,CHCIRr) causes two distinct types of liver damage. About 20% of halothane-exposed patients exhibit mild hepatotoxicity, characterized by transient elevations in liver enzymes. In contrast, a much smaller fraction of patients exposed to halothane (between 1 in 3500 and 1 in 35 000) develop severe hepatotoxicity, commonly termed ‘halothane h...
متن کاملHalothane-induced hepatitis: A forgotten issue in developing countries
Halothane was introduced as an anesthetic in the 1950s and was considered a revolutionary agent in the field of anesthesia. Soon after, halothane-induced hepatitis became a concern, leading to the development of less toxic gases that induced a lower incidence of side effects. Two types of halothane-related hepatotoxicity have been described: type 1, or mild hepatitis, is associated with elevate...
متن کاملNatural killer cells mediate severe liver injury in a murine model of halothane hepatitis.
Severe halothane (HAL)-induced hepatotoxicity occurs in one in 6000-30,000 patients by an unknown mechanism. Female sex is a risk factor in humans and rodents. We tested the hypothesis that a sex difference in natural killer (NK) cell activity contributes to HAL-induced liver injury. HAL (15 mmol/kg, ip) treatment resulted in severe liver injury by 12 h in female, wild-type BALB/cJ mice, and th...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1991
ISSN: 0007-0912
DOI: 10.1093/bja/67.1.84